Study on the relationship between polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia.
- Author:
Wei-Min JIANG
1
;
Shu-Hua TANG
;
Ren-Sheng LAI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Apolipoproteins E; genetics; Diagnosis, Differential; Female; Genotype; Humans; Hyperlipidemias; diagnosis; genetics; Male; Medicine, Chinese Traditional; Middle Aged; Polymorphism, Genetic; Yin Deficiency; genetics
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between the polymorphism of ApoE gene and TCM syndrome type of primary hyperlipemia.
METHODSApoE genotype of 102 patients with hyperlipemia was detected by gene PCR sequencing.
RESULTSA total of five genotypes were detectable, they were E2/2, E3/3, E4/4, E2/3 and E3/4. The frequency of E3/4 + E4/4 and epsilon4 allelotype detected in the patients of Gan-Shen Yin deficiency syndrome type were significantly higher than those in patients of Pi-Shen Yang-deficiency type or of phlegm stagnation type (P < 0.05, P < 0.01), and which in patients of Qi-stagnation caused blood stasis type were significantly higher than those in patients of phlegm stagnation type ( P < 0.05).
CONCLUSIONPolymorphism of ApoE gene is related in a certain degree to TCM syndrome type of primary hyperlipemia.
