Effects of raw rhubarb on plasma D-lactate and procalcitonin expressions in patients with sepsis.
- Author:
Xue-ling FANG
1
;
Qiang FANG
;
Jian-jun LUO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Calcitonin; blood; Calcitonin Gene-Related Peptide; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Lactic Acid; blood; Male; Middle Aged; Phytotherapy; Protein Precursors; blood; Rheum; Sepsis; blood; drug therapy
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(2):128-130
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of raw rhubarb (RR) on levels of plasma D-lactate and procalcitonin in patients with sepsis.
METHODSForty patients with sepsis enrolled were randomly divided into two groups, the RR group (n=18, treated with RR 9 g/d) and the control group (n=22, treated with conventional treatment). Plasma procalcitonin and D-lactate were determined before and after treatment.
RESULTSBefore treatment, there was no significant difference in the levels of plasma procalcitonin and D-lactate between the two groups (procalcitonin: 6.50 +/- 2.37 microg/L vs 6.98 +/- 2.89 microg/L; D-lactate: 0.18 +/- 0.05 mmol/L vs 0.19 +/- 0.06 mmol/L, P > 0.05). However, after treatment, two indexes in the RR group were significantly lower than those in the control group (procalcitonin: 4.11 +/- 1.40 microg/L vs 2.21 +/- 0.61 microg/L; D-lactate: 0.24 +/- 0.06 ng/L vs 0.09 +/- 0.03 ng/L, both P < 0.05).
CONCLUSIONRR could ameliorate the intestinal permeability and reduce the shifting of intestinal bacteria, so as to ease the condition of disease in patients with sepsis.
