Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury.
- Author:
Wan-Tie WANG
1
;
Li-Na LIN
;
Jin-Ze WU
;
Zhengyang HU
;
Kejian XIE
Author Information
- Publication Type:Journal Article
- MeSH: 6-Ketoprostaglandin F1 alpha; blood; Adult; Drug Therapy, Combination; Female; Humans; Lipid Peroxides; blood; Liver; blood supply; Liver Neoplasms; surgery; Male; Middle Aged; Propofol; therapeutic use; Pyrazines; therapeutic use; Reperfusion Injury; prevention & control; Superoxide Dismutase; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the protective effect and mechanism of ligustrazine (LGT) and propofol (PRO) on peri-operational liver ischemia-reperfusion injury (HIRI).
METHODSThirty-six patients scheduled for hepatic surgery were randomly divided into the control group, the LGT group, the PRO group and the LGT + PRO group, 9 patients in each group. Changes of superoxide dismutase (SOD), lipid peroxide (LPO), ratio of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1alpha (6-keto-PGF1alpha), alanine aminotransferase (ALT) activity, and the ultrastructure of liver tissue were dynamically observed.
RESULTSCompared with the control group, SOD activity was significantly higher, LPO concentration, TXB2/6-keto-PGF1alpha ratio and ALT value were significantly lower (P < 0.05 and P < 0.01) in the LGT group, the PRO group and the LGT + PRO group during HIRI, with the abnormal changes of hepatic ultrastructure 25 min after reperfusion significantly alleviated in the three treated group.
CONCLUSIONCombination of ligustrazine and propofol shows protective effect on liver by decreasing oxygen free radical level, reducing lipid peroxidation and adjusting TXA2/PGI2 imbalance after hepatic ischemia-reperfusion in patients undergoing hepatic cancer surgery.
