Effects of Xuezhikang on serum levels of high sensitive-C reactive protein, matrix metalloproteinase-9 and lipoprotein in patients with acute coronary syndrome.
- Author:
Jun HUANG
1
;
Meng-Hong WANG
;
Xiao-Ping PENG
;
Chunying WEI
;
Jun LU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Coronary Syndrome; blood; drug therapy; Adult; Aged; Angina, Unstable; blood; drug therapy; C-Reactive Protein; metabolism; Cholesterol; blood; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Lipoproteins, LDL; blood; Male; Matrix Metalloproteinase 9; blood; Middle Aged; Myocardial Infarction; blood; drug therapy; Phytotherapy; Triglycerides; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(3):221-223
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Xuezhikang (XZK) on serum levels of high sensitivity-C reactive protein (Hs-CRP), matrix metalloproteinase-9 (MMP-9) and lipoprotein in patients with acute coronary syndrome (ACS).
METHODSSixty-nine ACS patients were divided into the XZK group (40 cases) treated with conventional therapy and XZK and the control group (29 cases) with conventional therapy alone, another 30 healthy persons were assigned as the normal group. Before and after the treatment, the levels of Hs-CRP, MMP-9 and lipids were detected.
RESULTSCompared with those in the normal subjects, Hs-CRP and MMP-9 levels in the ACS patients increased significantly (P <0.05), parallel with the extent of myocardial injury. After 2 weeks of XZK treatment, levels of Hs-CRP and MMP-9 of the XZK group decreased significantly (P <0.05), while lipids levels had no remarkable changes.
CONCLUSIONHs-CRP and MMP-9 levels were closely correlated to the genesis and severity of ACS. Anti-inflammatory action of XZK plays an important role in early stage treatment of ACS patients.
