Effect of new qingkailing injection on cerebral edema following intracerebral hemorrhage in rats.
- Author:
Min LIU
1
;
Ming-Zhang GUO
;
Peng-Ying LI
;
Hanrui ZHANG
;
Lina LI
;
Pengtao LI
;
Qingguo WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Edema; etiology; metabolism; therapy; Cerebral Hemorrhage; chemically induced; complications; Collagenases; Drugs, Chinese Herbal; administration & dosage; Injections; Male; Matrix Metalloproteinase 9; blood; Neuroprotective Agents; administration & dosage; Phytotherapy; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Integrated Traditional and Western Medicine 2006;26(3):244-247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of New Qingkailing injection (NQKLI) on cerebral edema following intracerebral hemorrhage (ICH) induced by collagenase VII in rats.
METHODSAfter being established into ICH model by collagenase VII, rats were treated with NQKLI by intraperitoneal injection. Forty-eight hrs later, brain contents of water was detected with wet and dry method, calcium content in brain was detected by atomic spectrophotometer, tumor necrosis factor-alpha (TNF-alpha) in brain tissue was determined by liquid competitive ibhibitory immunoassay, and serum matrix metalloproteinase-9 (MMP-9) were detected with enzyme-linked immunosorbent assay (ELISA) respectively.
RESULTSNQKLI reduced the contents of water, calcium and TNF-alpha content of brain tissue and serum MMP-9 in rats with ICH.
CONCLUSIONNQKLI could alleviate both vasogenic and cytotoxic cerebral edema by prohibiting calcium over-load, protecting basilar membrane and eliminating inflammation.
