Impact of Platelet Function Test on Platelet Responsiveness and Clinical Outcome After Coronary Stent Implantation: Platelet Responsiveness and Clinical Outcome.
10.4070/kcj.2012.42.6.382
- Author:
Long Hao YU
1
;
Moo Hyun KIM
;
Hong Zhe ZHANG
;
Jong Seong PARK
;
Tae Ho PARK
;
Young Dae KIM
;
Kwang Soo CHA
;
Jin Yeong HAN
Author Information
1. Department of Cardiology, College of Medicine, Dong-A University, Busan, Korea. kimmh@dau.ac.kr
- Publication Type:Original Article
- Keywords:
Platelet function tests;
Coronary artery disease;
Drug-eluting stents
- MeSH:
Aspirin;
Blood Platelets;
Coronary Artery Disease;
Drug-Eluting Stents;
Female;
Follow-Up Studies;
Humans;
Male;
Multivariate Analysis;
Platelet Aggregation Inhibitors;
Platelet Function Tests;
Prospective Studies;
Stents;
Tetrazoles;
Ticlopidine
- From:Korean Circulation Journal
2012;42(6):382-389
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: The aim of this study was to confirm the predictive cut-off values for P2Y12 reaction units (PRU) and aspirin reaction units (ARU) and to evaluate the clinical impact of VerifyNow(R) assays. SUBJECTS AND METHODS: From November 2007 to October 2009, 186 eligible patients were prospectively recruited. Post-treatment platelet reactivity was measured by VerifyNow(R) assays within 12 to 24 hours after intervention, followed by standard dual maintenance dose therapy for 1 year. All patients had scheduled clinical follow-ups at 1, 3, 6, and 12 months. RESULTS: The rate of low responders to clopidogrel, aspirin, and both drugs were 41.4%, 10.2%, and 3.8%, respectively. The predictive factors for low responsiveness to clopidogrel (PRU > or =240) were female sex, age, and non-use of cilostazol medication in our univariate analysis and age > or =65 years and non-use cilostazol in the multivariate analysis. The predictors of low responsiveness to aspirin (ARU > or =550) were male sex and age in both univariate and multivariate analyses. There was no significant difference in the clinical event rate with a cut-off value of PRU > or =240 or ARU > or =550 for 30 days and 1-year (p>0.05). CONCLUSION: Hyporesponsiveness to antiplatelet agents (namely aspirin and clopidogrel) was identified in about half of the patients. The cut-off point of PRU > or =240 or ARU > or =550 did not confer predictive value for 30-day or 1-year clinical event rates in patients who had undergone coronary intervention with drug-eluting stents.
