Mechanism of cardiac atrophy under weightlessness/simulated weightlessness.
- Author:
Guo-Hui ZHONG
1
;
Shu-Kuan LING
1
;
Ying-Xian LI
2
Author Information
1. State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China.
2. State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China. yingxianli@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Atrophy;
Heart;
Heart Diseases;
Hemodynamics;
Humans;
NF-kappa B;
Space Flight;
Weightlessness;
Weightlessness Simulation
- From:
Acta Physiologica Sinica
2016;68(2):194-200
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac remodeling is the heart's response to external or internal stimuli. Weightlessness/simulated weightlessness leads to cardiac atrophy and heart function declining. Understanding the mechanism of cardiac atrophy under weightlessness is important to help astronaut recover from unloading-induced cardiovascular changes after spaceflight. Unloading-induced changes of hemodynamics, metabolic demands and neurohumoral regulation contribute to cardiac atrophy and function declining. During this process, Ca(2+)-related signaling, NF-κB signaling, ERK signaling, ubiquitin-proteasome pathway and autophagy are involved in weightlessness-induced cardiac atrophy. This article reviews the underlying mechanism of cardiac atrophy under weightlessness/simulated weightlessness.
