Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease.
- Author:
Wei CHEN
1
;
He-Sheng OU
2
Author Information
1. College of Pharmacy, Guangxi Medical University, Nanning 530021, China.
2. College of Pharmacy, Guangxi Medical University, Nanning 530021, China. hsou01@yahoo.com.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Cardiovascular Diseases;
Cell Differentiation;
Endothelial Cells;
Humans;
MicroRNAs
- From:
Acta Physiologica Sinica
2016;68(2):201-206
- CountryChina
- Language:Chinese
-
Abstract:
microRNA-24 (miR-24) belongs to miR-23~27~24 cluster. It is highly expressed in vascular endothelial cells (VECs), and plays an important role in the regulation of VECs specific gene expression. Recent studies indicate that miR-24 is involved in the regulation of VECs function such as proliferation, apoptosis, angiopoiesis, inflammation, and differentiation. The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease. In this review, we summarized the molecular mechanisms of miR-24 in regulating VECs function, and its role and importance during the development of cardiovascular disease.
