Role of eukaryotic translation initiation factor 4G in tumor.
- Author:
Si ZHANG
1
;
Nan HUANG
1
;
Xia PAN
1
;
Jing-Lei ZANG
1
;
Xin-Xin GUAN
1
;
Jian-Hua ZHANG
1
;
Liu-Cheng LIU
1
;
Xiao-Yong LEI
2
Author Information
1. Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China.
2. Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China. 1622214323@qq.com.
- Publication Type:Journal Article
- MeSH:
Eukaryotic Initiation Factor-4G;
Humans;
Neoplasms;
Protein Biosynthesis;
Up-Regulation
- From:
Acta Physiologica Sinica
2016;68(2):207-214
- CountryChina
- Language:Chinese
-
Abstract:
Eukaryotic translation initiation factor 4G (eIF4G) is a scaffold component of eukaryotic translation initiation factor 4F (eIF4F) complex, which takes principal part in the initiating of protein synthesis. Both two subtypes (eIF4G1 and eIF4G2) of eIF4G were found to be closely related with various tumors. The eIF4G1 expression is significantly up-regulated in breast cancer, cervical cancer, nasopharyngeal carcinoma, lung squamous cell carcinoma, prostatic carcinoma and other malignant tumors, compared with those in adjacent tissues; and the eIF4G2 is obviously over-expressed in diffuse large B cell lymphoma and acute myeloid leukemia, but low-expressed in bladder transitional cell carcinoma. This paper reviews the progress in the study of the role of eIF4G in tumor genesis, development, diagnosis and prognosis.
