Ambient modulation of neuronal excitability.
- Author:
Yi-Zhang CHEN
1
Author Information
1. Institute of Neuroscience, The Second Military Medical University, Shanghai 200433, China. chenyizhang1927@163.com.
- Publication Type:Journal Article
- MeSH:
Membrane Potentials;
Neurons
- From:
Acta Physiologica Sinica
2016;68(4):385-390
- CountryChina
- Language:Chinese
-
Abstract:
Although the modulation of synaptic activity plays an important role in the modulation of neuronal excitability, the significance of the ambient modulation (AM) of neuronal excitability should be emphasized. The AM refers to the alterations of membrane potential of neuron resulted from distinct neural activities, such as the tonic inhibition and excitation through activation of extra-synaptic receptors, the paracrine actions of nearby neural and non-neural cells, endocrinal actions of blood borne hormones and other active chemical substances. The AM of neuronal excitability may have important bearings on distinct brain functions, such as the regulation and switching of cortical states, the appearance of chaotic and vague feelings, which are usually the characteristic features in many mental and neural disorders.
