Advances in the association of ATP-sensitive potassium channels and Parkinson's disease.
- Author:
Xi-Xun DU
1
;
Kang QIN
1
;
Qian JIAO
1
;
Jun-Xia XIE
1
;
Hong JIANG
2
Author Information
1. Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071,China.
2. Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071,China. hongjiang@qdu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Dopaminergic Neurons;
Humans;
KATP Channels;
Mitochondria;
Oxidative Stress;
Parkinson Disease;
Synaptic Transmission
- From:
Acta Physiologica Sinica
2016;68(5):644-648
- CountryChina
- Language:Chinese
-
Abstract:
ATP-sensitive potassium channels (K), as an inward rectifying potassium channel, are widely distributed in many types of tissues. Kare activated by the depletion of ATP level and the increase in oxidative stress in cells. The activity of Kcouples cell metabolism with electrical activity and results in membrane hyperpolarization. Kare ubiquitously distributed in the brain, including substantia nigra, hippocampus, hypothalamus, cerebral cortex, dorsal nucleus of vagus and glial cells, and participate in neuronal excitability, mitochondria homeostasis and neurotransmitter release. Accumulating lines of evidence suggest that Kare the major contributing factors in the pathogenesis of Parkinson's disease (PD). This review discussed the association of Kwith the pathogenic processes of PD by focusing on the roles of Kon the degeneration of dopaminergic neurons, the functions of mitochondria, the firing pattern of dopaminergic neurons in the substantia nigra, the α-synuclein secretion from striatum, and the microglia activation.
