Study on modified guar gum microsphere as a protein drug carrier.
- Author:
Fuchu OU
1
;
Liming ZHANG
;
Rufu CHEN
Author Information
1. Institute of Polymer Science, School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
chemistry;
Drug Carriers;
chemistry;
Drug Delivery Systems;
Galactans;
chemistry;
Mannans;
chemistry;
Microspheres;
Plant Gums;
chemistry;
Proteins;
administration & dosage;
Serum Albumin, Bovine;
administration & dosage
- From:
Journal of Biomedical Engineering
2006;23(6):1267-1270
- CountryChina
- Language:Chinese
-
Abstract:
A biodegradable modified guar gum microsphere was prepared for the first time by ionic gelation of the guar gum derivative containing quarternary ammonium group with tripolyphosphate at room temperature in the absence of emulsifying agent or organic solvent. Its average particle diameter was about 140 microm and the particle size had a narrow and normal gauss distribution. From the loading experiment of bovine serum album (BSA) with various concentrations, it was found that the encapsulation efficiency is more than 80%. By the investigation of in vitro release from the BSA-loaded microsphere, it was found that the BSA had a continuous release for more than 6 hours and the release percentage was affected by the initial concentration of the BSA and temperature.
