Security evaluation of subcutaneous injection with water-based dextran-coated magnetic fluid.
- Author:
Yu ZHAI
1
;
Xiaoliang WANG
;
Xuman WANG
;
Hong XIE
;
Hongchen GU
Author Information
1. Engineering Research Center for Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200030, China. yzhai@sjtu.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Coated Materials, Biocompatible;
toxicity;
Dextrans;
toxicity;
Female;
Ferrosoferric Oxide;
toxicity;
Injections, Subcutaneous;
Magnetics;
Male;
Mice;
Mice, Inbred BALB C;
Random Allocation
- From:
Journal of Biomedical Engineering
2006;23(6):1275-1278
- CountryChina
- Language:Chinese
-
Abstract:
Water-based magnetic fluid was synthesized by using 50% dextran 40,000 as coated reagent. The acute toxicity and irritant of the magnetic fluid injected into mice subcutaneous tissues were examined. The lethal dosage 50 of dextran-coated magnetic fluid was 4409.61 +/- 514.93 mg/kg. Twenty four h after subcutaneous injecting with 30 mg/0.3 ml dextran-coated magnetic fluid, no more inflammation than hemangiectasia and leucocytes infiltration had been seen in subcutaneous tissues, 72 h later the reaction phenomena disappeared. While, injection with 30 mg/0.3 ml water-based oleate sodium-coated magnetic fluid, ulceration and break-off of cutis had been seen in the seventh days. That is to say, the dextran-coated magnetic fluid was safe and well tolerate, however, the oleate sodium-coated magnetic fluid was not fit to subcutaneous injection.
