Construction recombinant adenovirus vector expressing murine endostatin and inhibition of blood endothelial cells growth.
- Author:
Aiqing ZHENG
1
;
Xianrang SONG
;
Jinming YU
;
Ling WEI
;
Xingwu WANG
Author Information
1. Cancer Center, Affiliated Hospital, Tianjin Armed Police Medical University, Tianjin 300070, China.
- Publication Type:Journal Article
- MeSH:
Adenoviridae;
genetics;
metabolism;
Animals;
Apoptosis;
drug effects;
Cell Proliferation;
drug effects;
Cells, Cultured;
Endostatins;
biosynthesis;
genetics;
Endothelial Cells;
cytology;
Genetic Vectors;
genetics;
Humans;
Mice;
Recombinant Proteins;
biosynthesis;
genetics;
pharmacology;
Umbilical Veins;
cytology
- From:
Journal of Biomedical Engineering
2006;23(6):1294-1297
- CountryChina
- Language:Chinese
-
Abstract:
We constructed recombinant adenovirus vector expressing murine endostatin and evaluated the Inhibition of human umbilical vein endothelial cells (HUVEC). We proved that endostatin significantly suppressed the S phase fraction, inhibited proliferation and increased the apoptotic index of HUVEC.
