Time-frequency analysis of ventricular fibrillation and the effects of amiodarone.
- Author:
Ke WANG
1
;
Xiaoyan DENG
;
Zaipin XU
;
Shugang LI
;
Yan LIU
;
Ran GUO
;
Abhijit PATWARDHAN
;
Fabio LEONELLI
Author Information
1. Key Lab for Biomechanics & Tissue Engineering of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. kewang97@mail.diptt.ln.cn
- Publication Type:Journal Article
- MeSH:
Amiodarone;
pharmacology;
Animals;
Anti-Arrhythmia Agents;
pharmacology;
Dogs;
Electric Countershock;
Electrocardiography;
drug effects;
Female;
Male;
Ventricular Fibrillation;
physiopathology
- From:
Journal of Biomedical Engineering
2007;24(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
This study is to quantify time-varying dominant frequencies in electrocardiogram (ECG) during the ventricular fibrillation (VF). Orthogonal ECG (sagittal, x; transverse, y; and longitudinal, z) and the transvenous two-leads defibrillation systems were set in 19 dogs. Time-frequency analysis was used to assess changes in the dominant frequency within ECG recorded in dogs during trials of 10-30 s of VF. In 4 additional dogs, the dominant frequencies were compared during 10 s of VF before and after administration of amiodarone. Results showed that in the 427 trials of 10 s VF and 335 trials of 30 s VF, average variation in the dominant frequency was considerable, between +/- 12%-18%. The frequencies orthogonal ECG during 10 s VF were distributed symmetrically above and below the mean frequency like a normal distribution. In the 79 trials with administration of amiodarone during 10 s VF in all three ECG, the mean frequencies decreased from 6.5 (x), 7.4 (y) and 7.0 Hz (z) to 6.1, 6.4 and 6.3 Hz (P < 0.01), respectively, and the variation in dominant frequencies decreased from 1.18, 1.38 and 1.19 to 0.98, 1.11 and 1.02 Hz (P < 0.05) respectively. The results confirmed that the frequencies of 10-30 s VF in ECG vary considerably and continuously, and amiodarone decreases this variation.
