Expression of prognostic factors (EGFR, ER) by immunohistochemical staining method in male breast cancer.
10.3349/ymj.1991.32.2.126
- Author:
Hyun Cheol CHUNG
1
;
Dong Lip KIM
;
Eun Hee KOH
;
Joo Hang KIM
;
Jae Kyung ROH
;
Jin Sik MIN
;
Kyung Sik LEE
;
Woo Ick YANG
;
Byung Soo KIM
;
Kyi Beom LEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Male breast cancer;
EGFR;
ER
- MeSH:
Breast Neoplasms/*chemistry/pathology;
Carcinoma/*chemistry/pathology;
Human;
Immunohistochemistry;
Lymphatic Metastasis;
Male;
Neoplasm Staging;
Prognosis;
Receptor, Epidermal Growth Factor/*analysis;
Receptors, Estrogen/*analysis
- From:Yonsei Medical Journal
1991;32(2):126-130
- CountryRepublic of Korea
- Language:English
-
Abstract:
Twelve male patients with operable breast cancer were evaluated for the expression of prognostic factors by immunohistochemical staining assay. Seven patients were stage I and II, and five patients were stage III. Axillary lymph node positivity was 42%. Nine patients were nuclear grade I, three were nuclear grade II, and none were nuclear grade III. The expression rate of EGFR (epidermal growth factor receptor), ER (estrogen receptor) were 8.3%, 70.0% respectively. This limited data suggest better tumor behavior in male than in female breast cancer. Adjuvant treatment should be considered in male breast cancer just as in females, based on axillary lymph node and ER states.
