Clinicopathologic significance of CD105 mRNA expression in human breast carcinoma.
- Author:
Da PANG
1
;
Feng LIU
;
Ying-Wei XUE
;
Qi-Fan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antigens, CD; Biomarkers, Tumor; metabolism; Breast Neoplasms; metabolism; pathology; Carcinoma, Ductal, Breast; metabolism; pathology; secondary; Endoglin; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; RNA, Messenger; biosynthesis; genetics; Receptors, Cell Surface; Vascular Cell Adhesion Molecule-1; biosynthesis; genetics
- From: Chinese Journal of Oncology 2005;27(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study endoglin (CD105) gene expression in breast cancer and its clinicopathologic significance.
METHODSIn 40 patients with breast cancers, CD105 mRNA was detected at center and periphery of tumor and at nearby normal tissue by RT-PCR.
RESULTSThe difference in CD105 mRNA expressions between cancer and normal breast tissue was significant (t = 12.08, P < 0.05), and the expression was significantly higher at the tumor periphery than at the tumor center (t = 7.52, P < 0.05). CD105 over-expression was related to lymph node metastases (t = 2.71, P < 0.05), but not to age, tumor size, pathologic grade or pathologic type (P > 0.05).
CONCLUSIONCD105 over-expression may play a crucial role in the progression of breast cancer and lymph node metastasis.
