Glutathione S-transferase T1, M1 gene polymorphism in leukemia patients in Shanghai area.
- Author:
Li-li ZOU
1
;
Guo-fang LIN
;
Qing-wen MA
;
Dong-sheng ZHANG
;
Jian-hua SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Age Factors; Aged; China; Female; Genetic Predisposition to Disease; Glutathione Transferase; genetics; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; enzymology; genetics; Leukemia, Myeloid, Acute; enzymology; genetics; Male; Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; enzymology; genetics; Sex Factors
- From: Chinese Journal of Oncology 2004;26(11):649-651
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possible association of polymorphisms of glutathione S-transferases T1, M1 genes and leukemia susceptibility.
METHODSAS-PCR procedure was applied to determine the GSTs genotypes in a group of leukemia patients (n=61) in Shanghai area. The genotype frequencies in the leukemia patients and normal controls (183 healthy residents in the same city) were compared. Stratification with leukemia types, age and gender was made for further comparison.
RESULTSThe frequencies of GSTT1 0/0 genotype and GSTT1 0/0-GSTM1 0/0 combined genotype were higher in leukemia patients than in controls, and the differences were significant. When stratified with age and gender, this trend still existed in the male ALL patients and in younger ALL patients (age < or = 30).
CONCLUSIONIndividuals who bear GSTT1 0/0 genotype or GSTT1 0/0-GSTM1 0/0 combined genotypes are more susceptible to leukemia, especially for male and younger carriers.
