Apoptosis-related gene expression and its clinical significance of human osteosarcoma.
- Author:
Xing WU
1
;
Zheng-rong CHEN
;
Guang-jian ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Apoptosis; Biomarkers, Tumor; Bone Neoplasms; metabolism; pathology; Disease Progression; Female; Follow-Up Studies; Humans; Male; Osteosarcoma; metabolism; pathology; Prognosis; Proto-Oncogene Proteins c-bcl-2; metabolism; Survival Rate; Tumor Suppressor Protein p53; metabolism; bcl-2-Associated X Protein
- From: Chinese Journal of Oncology 2004;26(11):678-681
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the prognostic markers in osteosarcoma.
METHODSExpressions of p53, c-myc, bcl-2 and apoptosis index (AI) in 28 osteosarcoma specimens were detected by ABC immunohistochemistry and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-digoxigenin nick end labelling (TUNEL). The relationship between gene expression and apoptosis, and their correlations with pathologic classification and prognostic factors were analyzed.
RESULTSThere was negative correlation between the expressions of p53, c-myc, bcl-2 protein and AI, which was closely related to the long term survival of patients but was not related to pathologic types of the tumor.
CONCLUSIONThe expressions of p53, c-myc, bcl-2 protein and AI can be used as an index for predicting the progression and prognosis of osteosarcoma.
