Correlation between expression of matrix metalloproteinase-2 and angiogenesis in esophageal carcinoma.
- Author:
Jie-ru LI
1
;
Feng-ying QI
;
Li LI
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; blood supply; enzymology; secondary; Esophageal Neoplasms; blood supply; enzymology; pathology; Female; Humans; Lymphatic Metastasis; Male; Matrix Metalloproteinase 2; metabolism; Microcirculation; enzymology; pathology; Middle Aged; Neovascularization, Pathologic; enzymology; pathology
- From: Chinese Journal of Oncology 2005;27(2):96-98
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study expression of MMP-2 in relation to microvessel density (MVD) in esophageal carcinoma.
METHODSForty-eight specimens of esophageal carcinoma (Ec) and 17 specimens of grade II + III epithelial dysplasia (Dy) close to the tumor and 12 specimens of normal tissue (Nt) along the incisional margin were examined by S-P immunohistochemical staining with anti-MMP-2 monoclonal antibody. An anti-CD34 monoclonal antibody was used to show MVD.
RESULTSMMP-2 expression in Ec was remarkably higher than that in Dy, which was higher than that in Nt. MMP-2 expression in Ec and Dy was significantly correlated with MVD in the tumor and nearby tissue. MMP-2 expression and MVD in Ec significantly associated with lymph node metastasis.
CONCLUSIONExpression of MMP-2 plays an important role in angiogenesis and lymph node metastasis of esophageal cancer.
