Correlation between expression of MMP-2, MMP-9, TIMP-2, TIMP-1 and metastasis of neuroblastoma.
- Author:
Yu CHENG
1
;
Qian DONG
;
Li-rong SUN
;
Chuan-min YANG
;
Bu-xian JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Child; Child, Preschool; Female; Humans; Infant; Lymphatic Metastasis; Male; Matrix Metalloproteinase 2; metabolism; Matrix Metalloproteinase 9; metabolism; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neuroblastoma; enzymology; metabolism; secondary; Retroperitoneal Neoplasms; enzymology; metabolism; pathology; Testicular Neoplasms; enzymology; metabolism; secondary; Tissue Inhibitor of Metalloproteinase-1; metabolism; Tissue Inhibitor of Metalloproteinase-2; metabolism
- From: Chinese Journal of Oncology 2005;27(3):164-166
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study MMP-2, MMP-9, TIMP-2 and TIMP-1 expression, and their association to invasion and metastasis of neuroblastoma (NB).
METHODSThe staining status was compared of MMP-2, MMP-9, TIMP-2 and TIMP-1 in cryostat sections of tumor tissue in 35 NB patients by immunohistochemistry.
RESULTSStrong expression of MMP-2 was detected only in 2 patients with early stage NB (group A without metastasis), but in 9 and 10 respectively with advanced stage NB (group B with local metastasis and group C with distant metastasis) (compared to group A, P < 0.01). Strong MMP-9 staining was found in 4, 8 and 11 patients for group A, B and C patients (group A vs group C, P < 0.05). The expression of TIMP-2 was the strongest in 4 group A patients, but it decreased with progression of the disease. There was no statistical difference in TIMP-1 expression among the three groups of patients.
CONCLUSIONMMP-2, MMP-9 expression may be related to metastasis and progression of neuroblastoma, while TIMP-2 may have an inhibitory effect.
