Expression and clinical significance of KISS-1 and GPR54 mRNA in endometrial carcinoma.
- Author:
Tao JIANG
1
;
Shu-lan ZHANG
;
Bei LIN
;
Li-rong MENG
;
Hong GAO
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; Adult; Aged; Endometrial Neoplasms; metabolism; pathology; Female; Humans; Kisspeptins; Middle Aged; Neoplasm Metastasis; RNA, Messenger; biosynthesis; genetics; Receptors, G-Protein-Coupled; biosynthesis; genetics; Receptors, Kisspeptin-1; Tumor Suppressor Proteins; biosynthesis; genetics
- From: Chinese Journal of Oncology 2005;27(4):229-231
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression and clinical significance of KISS-1 mRNA and GPR54 mRNA in endometrial carcinoma.
METHODSThe expression of KISS-1 mRNA and GPR54 mRNA in 32 patients with endometrial carcinoma, 10 patients with endometrial intraepithelial neoplasia (EIN) and 12 patients with normal endometrium was detected by reverse transcriptase polymerase chain reaction (RT-PCR).
RESULTSThe positive rate of KISS-1 mRNA in endometrial carcinoma, EIN and normal endometrium was 37.5%, 80.0% and 83.3% respectively (endometrial carcinoma vs EIN or normal endometrium, P < 0.05). The expression of KISS-1mRNA in patients with endometrial carcinoma was correlated with its clinical stage, myometrial invasion and lymph node metastasis (P < 0.05). In endometrial carcinoma, the more advanced clinical stage, the lower expression of KISS-1 mRNA was detected. The positive rate of GPR54 mRNA in endometrial carcinoma, EIN and normal endometrium was 78.1%, 70.0% and 66.7% respectively, with no significant statistical difference (P > 0.05). It was not correlated with the clinical stage, histology grade, myometrial invasion or lymph node metastasis (P > 0.05).
CONCLUSIONThe interaction of KISS-1 and GPR54 may play an important role in inhibiting the invasion and metastasis of endometrial carcinoma.
