Assessment of fibrosis during the development of fatty liver in rabbits using real-time shear-wave elastography.
10.1007/s11596-014-1375-0
- Author:
Yong-ping LU
1
;
Jia WEI
;
Li-rong XU
;
Yue-yue TANG
;
Yuan YUAN
;
Yong ZHANG
;
Yun-yan LI
Author Information
1. Department of Ultrasound, The Fourth Affiliated Hospital of Kunming Medical University, The Second People's Hospital of Yunnan Province, Kunming, 650021, China, luyongp@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Elasticity;
Elasticity Imaging Techniques;
methods;
Fatty Liver, Alcoholic;
complications;
diagnostic imaging;
Liver Cirrhosis;
diagnostic imaging;
etiology;
Male;
Non-alcoholic Fatty Liver Disease;
complications;
diagnostic imaging;
Rabbits
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2014;34(6):921-928
- CountryChina
- Language:English
-
Abstract:
Nonalcoholic and alcoholic rabbit models of fatty liver were established by feeding on high-fat diet and alcohol, respectively, and fatty liver stiffness at different pathological stages was assessed with real-time shear-wave elastography (SWE), so as to investigate the fibrosis process during the development of fatty liver. The fatty liver stiffness of rabbit in nonalcoholic and alcoholic groups was higher than that in the control group, and that in alcohol group was higher than that in the nonalcoholic group (P<0.01). The elasticity modulus of liver in fatty liver rabbits of nonalcoholic and alcoholic groups showed a positive correlation with progression of liver fibrosis (P<0.01). Real-time SWE, as a noninvasive diagnostic method, can objectively reflect the liver stiffness change and progression of liver fibrosis during the development of fatty liver.
