Efficacy of telbivudine in the treatment of chronic hepatitis b and liver cirrhosis and its effect on immunological responses.
10.1007/s11596-015-1416-3
- Author:
Nan MENG
1
;
Xiao GAO
;
Wei YAN
;
Mi WANG
;
Ping LIU
;
Xiao-dan LU
;
Shu-juan ZHANG
;
Ya-qi LU
;
Wang-xian TANG
Author Information
1. Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, mn906125598@126.com.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Antiviral Agents;
therapeutic use;
Female;
Hepatitis B, Chronic;
drug therapy;
immunology;
Humans;
Liver Cirrhosis;
drug therapy;
immunology;
Male;
Middle Aged;
Thymidine;
analogs & derivatives;
therapeutic use
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2015;35(2):230-234
- CountryChina
- Language:English
-
Abstract:
This study was aimed to evaluate the long-term effects of telbivudine (LdT) in the treatment of chronic hepatitis B (CHB) and HBV-related liver cirrhosis (LC) and to observe the changes of immunological responses during LdT treatment. Clinical data of 80 CHB and 28 HBV-related LC patients who were administered with LdT for 108 weeks and followed up were retrospectively analyzed. The liver function indicators including ALT, AST and γ-GT, HBV DNA copy number in serum and the rates of hepatitis B e antigen (HBeAg) seroconversion were analyzed before and 12, 24, 36, 48, 60, 72, 84, 96 and 108 weeks after LdT treatment in CHB and LC groups. Four serum fibrosis-related markers, including hyaluronic acid (HA), human laminin (LN), human type IV collagen (IV-C) and human N-terminal procollagen III peptide (PC-III), were detected before and after LdT treatment in LC group. The results showed favorable viral suppression and biochemical responses after treatment with LdT for 12 weeks, and a high rate of virological and biochemical control was maintained during the course of 108-week treatment in both CHB and LC groups. The four fibrosis-related markers, especially HA and LN, were down-regulated to some degrees in LC group. Moreover, LdT treatment led to the fluctuation of the circulating interferon-γ (IFN-γ) and interleukin-10 (IL-10) levels at different time points in CHB group. It was concluded that LdT could favorably lead to the virological suppression and biochemical remission. Besides, IFN-γ and IL-10 may represent a suitable and effective predictor of responsiveness during LdT therapy.
