Association between EGF +61 A>G polymorphism and gastric cancer risk: A meta-analysis.
10.1007/s11596-015-1432-3
- Author:
Song-Jie WU
1
;
Si-Yu JIANG
;
Jing WU
;
Guang-Lian XIONG
Author Information
1. Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China, wsj923@126.com.
- Publication Type:Journal Article
- MeSH:
Asian Continental Ancestry Group;
genetics;
EGF Family of Proteins;
genetics;
Epidermal Growth Factor;
genetics;
Genetic Association Studies;
Genetic Predisposition to Disease;
Humans;
Polymorphism, Single Nucleotide;
Regression Analysis;
Stomach Neoplasms;
genetics
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2015;35(3):327-332
- CountryChina
- Language:English
-
Abstract:
Previous studies suggested an association between the EGF +61 A>G polymorphism and susceptibility to gastric cancer, but the results have been inconsistent. To draw a more precise risk estimation of the association, we performed a meta-analysis of published studies. PubMed, EMBASE, Google Scholar and the Chinese Wanfang databases were systematically searched to identify relevant studies. There were 7 studies involving 1992 cases of gastric cancer and 3202 controls in this meta-analysis. Our study showed that, overall, the EGF +61 A>G polymorphism was significantly associated with the increased risk of gastric cancer in allele model (G vs. A: OR=1.18, 95% CI=1.00-1.39), dominant model (GG + GA vs. AA: OR=1.28, 95% CI=1.05-1.55), homozygous model (GG vs. AA: OR=1.31, 95% CI=1.06-1.63) and heterozygous model (GA vs. AA: OR=1.25, 95% CI=1.01-1.53). The stratified analysis by ethnicity revealed a significant association between EGF +61 A>G polymorphism and gastric cancer risks in Asians. This meta-analysis indicates that EGF +61 A>G polymorphism may increase the risk of gastric cancer, especially in Asians. Large-sized, well-designed studies involving different ethnic groups should be conducted to confirm this association.
