Research advances of multiple myeloma immunophenotyping.
- Author:
Yan PANG
1
;
Li LI
;
Li-Ping KUANG
;
Yang XIAO
Author Information
1. Department of Hematology, Guangzhou General Hospital, Guangdong Province, China.
- Publication Type:Journal Article
- MeSH:
Flow Cytometry;
Humans;
Immunophenotyping;
Multiple Myeloma;
diagnosis;
immunology;
Prognosis
- From:
Journal of Experimental Hematology
2011;19(6):1518-1522
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma (MM) is a clonal B-cell disorder in which malignant plasma cells (PC) accumulate in the bone marrow and produce lytic bone lesions and excessive amounts of monoclonal immunoglobulin. The diagnosis of MM requires the examination of bone marrow, showing PC infiltration, detection and quantification of monoclonal immunoglobulin in the serum or urine and evidence of organ damage (hypercalcemia, renal insufficiency, anaemia or bone lesions). This review discusses the significance of immunotyping for diagnosis and prognosis of MM.
