Research progress and application of BCR/ABL transgenic animal model.
- Author:
Yu-Feng ZHU
1
;
Yuan-Zhan WANG
;
Fan-Yi MENG
Author Information
1. Southern Medical University, Guangzhou, Guangdong Province, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Animals, Genetically Modified;
Disease Models, Animal;
Fusion Proteins, bcr-abl;
genetics;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- From:
Journal of Experimental Hematology
2011;19(6):1532-1535
- CountryChina
- Language:Chinese
-
Abstract:
Transgenic animal model provide a good platform to research the pathogenesis and therapy of chronic myelogenous leukemia (CML). To date, a number of BCR/ABL transgenic animal models have been established using different promoter or tetracycline-controlling system. Some of them appear the characteristics of human CML, which have contributed greatly to research the pathogenesis and therapy of CML. In this article, the researching progress, advantage and drawback, application of BCR/ABL transgenic animal model are reviewed.
