Progress of cytogenetic detection in myelodysplastic syndromes.
- Author:
Qing-Bing ZHOU
1
;
Xiao-Mei HU
;
-Feng LIU
;
Rou MA
Author Information
1. Department of Hematology, China Academy of Chinese Traditional Medical Sciences, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Comparative Genomic Hybridization;
methods;
Cytogenetics;
methods;
Humans;
Karyotype;
Karyotyping;
Myelodysplastic Syndromes;
diagnosis;
genetics;
Polymorphism, Single Nucleotide;
Prognosis
- From:
Journal of Experimental Hematology
2011;19(6):1536-1540
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, significant progresses have been got in study on pathogenesis, treatment and prognosis of myelodysplastic syndromes (MDS), especially on use of new technology, that has great importance for cytogenetics of MDS. Recently, the progress of cytogenetic detection in MDS is very remarkable. Based on the metaphase cytogenetics (MC) method, prognostic significance of cytogenetics in MDS was clarified gradually. For example, people have known the prognostic significance of 12 p-, 11 q-, +21, t(11(q23)), although these genetic abnormalities are rare in the MDS. In addition, chromosome mutation emerged in the process of MDS may indicate the poor prognosis. On the other hand, with the use of SNP-A and aCGH in the study of genetics, MDS cytogenetic abnormality detection rate has been further improved and can reach to 78%. At the same time, some of MDS patients with the "normal karyotype" detected by MC have new hidden aberrations through the SNP or CGH detection, and these patients have a poorer prognosis. In this review, the advances of study on cytogenetic detection for MDS based on MC and SNP-A or aCGH methods are summarized.
