Recent research advances on cryopreserved platelets.
- Author:
Tao WU
1
;
Jing-Han LIU
Author Information
1. Department of Blood Transfusion, Chinese PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Blood Platelets;
Blood Preservation;
methods;
Cryopreservation;
Cryoprotective Agents;
Dimethyl Sulfoxide;
Dogs;
Humans
- From:
Journal of Experimental Hematology
2012;20(1):224-228
- CountryChina
- Language:Chinese
-
Abstract:
The right choice of frozen protective agents and additives is an important factor to ensure the quality of frozen platelets. The immediate hemostatic function of frozen platelet in vivo is superior to liquid-stored platelets. In order to ensure the quality of frozen platelets better, it is important to understand the role of dimethylsulfoxide (DMSO) in the preservation of frozen platelets and its mechanism, and to understand the mechanism of DMSO enhancing the hemostatic function of frozen platelets and the effects of different factors on the frozen platelets. In this review, the long-term preservation of frozen platelets and its quality standards, the mechanism of DMSO effect on the molecular changes and inhibition of frozen platelets, different factors influencing preservation freezing platelets and the test of preservation effects, the application of frozen platelets to the military operation and disaster relief, the canine frozen platelet studies and so on are summarized.
