Expressions of miR-21, miR-155 and miR-210 in plasma of patients with lymphoma and its clinical significance.
- Author:
Tian-Tian GE
1
;
Yong LIANG
;
Rong FU
;
Guo-Jin WANG
;
Er-Bao RUAN
;
Wen QU
;
Xiao-Ming WANG
;
Hong LIU
;
Yu-Hong WU
;
Jia SONG
;
Hua-Quan WANG
;
Li-Min XING
;
Jing GUAN
;
Li-Juan LI
;
Zong-Hong SHAO
Author Information
1. Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Case-Control Studies;
Female;
Humans;
Lymphoma;
blood;
diagnosis;
Male;
MicroRNAs;
blood;
Middle Aged;
Plasma;
metabolism;
Prognosis;
Young Adult
- From:
Journal of Experimental Hematology
2012;20(2):305-309
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the expressions of miR-21, miR-155 and miR-210 in plasma of patients with lymphoma, and explore their role played in diagnosis, evaluation of chemotherapy effect and prognosis of lymphoma. The expressions of miR-21, miR-155 and miR-210 were assayed by RT-PCR in plasma of 54 cases of lymphoma, 10 cases of lymphonode inflammation and 27 cases of normal controls. The results indicated that the expressions of miR-21, miR-155 and miR-210 in plasma of lymphoma patients were higher than those of control group and lymphonode inflammation group (P < 0.05). The expressions of miR-21 and miR-210 in plasma of control group and lymphonode inflammation group had no significant differences (P > 0.05). The expression of miR-21 in plasma of lymphoma patient group significantly correlated with their serum LDH level. The expressions of miR-21 and miR-210 in plasma of previously untreated lymphoma patient group were higher than those of the patients treated for 6 or more courses (P < 0.05). The diagnostic accuracy of miR-21, miR-155 and miR-210 used for lymphoma patients was 56, 65, 48 respectively, and reached to 83 when combined three of them. It is concluded that the expressions of miR-21, miR-155 and miR-210 in plasma of lymphoma patients were significantly higher. Detection of these 3 miRNA in plasma of patients can contribute to the clinical diagnosis, treatment and prognosis evaluation of lymphoma.
