Predictive value of tissue factor-associated platelet microparticles in thrombosis of patients with lymphoma.
- Author:
Yun-Long TANG
1
;
Yan ZHOU
;
Chun-Bin WANG
;
Yan QIN
;
Jian FENG
;
Jing QIN
Author Information
1. Department of Hematology, Southeast University Medical College, Yanchen, China.
- Publication Type:Journal Article
- MeSH:
Blood Platelets;
pathology;
Case-Control Studies;
Cell-Derived Microparticles;
pathology;
Flow Cytometry;
Humans;
Lymphoma;
complications;
pathology;
Thromboplastin;
metabolism;
Thrombosis;
complications;
pathology
- From:
Journal of Experimental Hematology
2012;20(2):325-328
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the relationship between tissue factor associated platelet microparticles and thrombosis of patients with lymphoma by detecting the density of platelet microparticles and the tissue factor coagulative activity, and to evaluate the possibility of tissue factor coagulative activity for predication of thrombosis in lymphoma patients. This study was divided into 3 groups: A group including 50 healthy persons who did not take any drugs and had no hypercoagulation diseases; B group including 50 cases of lymphoma without thrombosis, and C group including 8 cases of lymphoma with thrombosis. The plasma was isolated from venous blood by centrifugation. The density of platelet microparticles was detected by flow cytometry; the tissue factor coagulative activity of plasma was measured by chromogenic substrate. The results indicated that compared with group A, the density of platelet microparticles increased in group B. Compared with group B, group C had significantly higher density of platelet microparticles and tissue factor coagulative activity (P < 0.01). It is concluded that the density of tissue factor associated platelet microparticle has predictive value for lymphoma with thrombosis, which can be used as target of clinical test.
