Anti-endotoxic effects of syringic acid of Radix Isatidis.
- Author:
Yunhai LIU
1
;
Jianguo FANG
;
Ting LEI
;
Wenqing WANG
;
Aihua LIN
Author Information
1. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
- Publication Type:Journal Article
- MeSH:
Animals;
Drugs, Chinese Herbal;
pharmacology;
Endotoxemia;
blood;
Endotoxins;
antagonists & inhibitors;
Escherichia coli;
Female;
Gallic Acid;
analogs & derivatives;
pharmacology;
Isatis;
chemistry;
Limulus Test;
Male;
Mice;
Plant Roots;
chemistry;
Rabbits
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2003;23(2):206-208
- CountryChina
- Language:English
-
Abstract:
The anti-endotoxic effect of syringic acid (SA) isolated from Radix Isatidis (Banlangen, BLG) was studied. SA was extracted and isolated from BLG and diluted into 1% solution. The content of SA-pretreated endotoxin (ET) was quantitatively determined using Limulus test. The ability of fever induction of ET pretreated with SA was measured using endotoxin-induced fever test in rabbits. The LPS-induced death in mice pretreated with and without SA was compared. Results showed that after pretreatment with SA, 83.16% of ET was destroyed, the ET-induced fever in rabbits relieved markedly and the LPS-induced death rate in mice dropped from 68% to 20%. It was concluded that SA isolated from BLG had anti-endotoxic effects.
