Simultaneous determination of ibuprofen and pseudoephedrin hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin tablets by HPLC.
- Author:
San-fu YIN
1
;
Zong-yin QIU
Author Information
- Publication Type:Journal Article
- MeSH: Chlorpheniramine; analysis; Chromatography, High Pressure Liquid; methods; Ibuprofen; analysis; Pseudoephedrine; analysis; Tablets; chemistry
- From: Journal of Southern Medical University 2010;30(7):1703-1704
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEAn HPLC method was developed to determinate Ibuprofen and Pseudoephedrine Hydrochloride and Chlorpheniramine Maleate in Compound BuluoWeimaNamin Tablets.
METHODSUsing HPLC with Kromasil C18 column, and acetonitrile -0.5% SDS- phosphate (580:420:1) as the mobile phase. The wavelength for detection was 262 nm.
RESULTSBetter linearities and good correlation coefficients were obtained: the concentration ranges of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were over 2.062-14.434 microg (r=0.9999), 0.296-2.072l microg (r=0.9999), and 0.0204~0.1428 microg (r=0.9998), respectively. The recoveries of ibuprofen, pseudoephedrine hydrochloride and chlorpheniramine maleate were 99.98% (RSD=0.52%), 99.72 (RSD=0.82%) and 99.545 (RSD=0.76%), respectively.
CONCLUSIONThe method was convenient, accurate and specific. It can be used as a method to control quality of Compound Buluoweimanamin Tablets.
