Expression of pituitary tumor transforming gene in human renal clear cell carcinoma and its significance.
- Author:
Ming-hua TANG
1
;
Jian TAN
;
Fei-lun CUI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Renal Cell; metabolism; pathology; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Kidney Neoplasms; metabolism; pathology; Male; Middle Aged; Neoplasm Proteins; genetics; metabolism; Securin
- From: Journal of Southern Medical University 2010;30(7):1712-1714
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of pituitary tumor transforming gene (PTTG) in human renal clear cell carcinoma (RCCC) and its significance.
METHODSPTTG protein expression was detected by immunohistochemistry in 87 RCCC and 45 paired normal renal tissues.
RESULTSPTTG was expressed differentially between the normal renal and RCCC tissues. Compared with normal tissues, the primary RCCC tissues showed significantly increased expression of PTTG protein (P<0.001). The positive rate of PTTG protein was positively correlated to the tumor size, clinical stage and Fuhrman grade of RCCC (P=0.009, 0.008 and 0.035, respectively).
CONCLUSIONIncreased PTTG protein expression may be involved in the carcinogenesis and progression of RCCC.
