GABAergic neurons in the central nucleus of amygdala modulate sodium appetite in rats.
- Author:
Qian WANG
1
;
Jian-qun YAN
;
Jin-rong LI
;
Ke CHEN
;
Bo SUN
;
Shi-ru ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Amygdala; cytology; metabolism; Animals; GABAergic Neurons; metabolism; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; metabolism; Sodium, Dietary
- From: Journal of Southern Medical University 2010;30(8):1783-1786
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine whether the GABA-containing neurons in rat central nucleus of amygdala (CeA) can be activated by acute sodium deprivation.
METHODSAcute sodium depletion was induced by subcutaneous injection of furosemide in rats followed by 24 h of dietary sodium deprivation. The rats underwent 0.3 mol/L NaCl/distilled water two bottle choice test, and the activated neurons were labeled and identified with GABA/Fos-double labeling immunohistochemistry.
RESULTSThe rats with acute sodium depletion exhibited significantly more numerous c-fos-positive neurons and GABA/Fos double-labeled neurons in the CeA than the control group (P<0.01, P<0.05). Consumption of 0.3 mol/L NaCl significantly increased the number of c-fos and GABA/Fos double labeled neurons compared to the distilled water group (P<0.001, P<0.01).
CONCLUSIONGABAergic neurons in the CeA may play an inhibitory role in the regulation of sodium intake in rats with acute sodium depletion.
