Preparation of As2O3 nanoparticles and its drug release characteristics in vitro.
- Author:
Li-shu XU
1
;
Jian-hu LIU
;
Ping LIN
;
Kai-hong HUANG
;
Yin-ting CHEN
;
Qi-kui CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Arsenicals; administration & dosage; chemical synthesis; pharmacokinetics; Drug Carriers; Nanoparticles; Oxides; administration & dosage; chemical synthesis; pharmacokinetics; Particle Size; Polyglycolic Acid
- From: Journal of Southern Medical University 2010;30(8):1790-1792
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare arsenic trioxide (As2O3)-loaded biodegradable polylactic-co-glycolic acid (PLGA) nanoparticles (NPS) and evaluate the glomeration ability, appearance, structure, surface and release characteristics of the NPs.
METHODSWith PLGA as the carrier material, As2O3 NPs (As2O3-NPS) were prepared with the method of matrix and ultrasound emulsification. According to the criteria of the diameter of the NPs, drug loading (DL) and embedding ratio (ER), the process of NP preparation was optimized by scanning electron microscopy (SEM), ultraviolet spectroscopy (UV), and XPS.
RESULTSThe As2O3-NPS prepared were uniformly spherical with an average diameter of 210-/+23 nm, DL of 29.6% and ER of 82.1%. The drug release assay in vitro showed a sustained drug-release capacity of the preparation.
CONCLUSIONAs2O3-NPS may serve as a carrier of As2O3 to change the pharmacokinetics of As2O3 in vivo, allow slow drug release, and prolong the drug circulation time after intravenous injection, thereby producing better antitumor effects.
