Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis.
- Author:
Hua YI
1
;
Yue LU
;
Jian-kun CHEN
;
Biao-yan DU
;
Ai-jun LIU
;
Hui LUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Choristoma; metabolism; Danazol; pharmacology; Endometriosis; metabolism; Female; Morphinans; pharmacology; NF-kappa B; metabolism; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; metabolism
- From: Journal of Southern Medical University 2010;30(8):1874-1876
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of sinomenine on the level of tumor necrosis factor-alpha (TNF-alpha) and nuclear factor-kappaB (NF-kappaB) and in the heterotopic tissue in rats with endometriosis.
METHODSThe rats with endometriosis were divided into sinomenine lavage group, blank control group, model group and danazol group, and the levels of TNF-alpha and NF-kappaB in the heterotopic tissues of the rats were detected with immunohistochemistry.
RESULTSSinomenine lavage and danazol treatment both significantly decreased the levels of levels of TNF-alpha and NF-kappaB in the heterotopic tissues of the rats as compared with the model group (P<0.05), and lesions were significantly smaller in sinomenine lavage group than in danazol group.
CONCLUSIONSinomenine can inhibit the production and activity of TNF-alpha and NF-kappaB to suppress the adhesion, implantation, infiltration and growth of the endometrial cells in the rat model of endometriosis.
