Correlation of ornidazole concentration in saliva and serum of healthy volunteers.
- Author:
Yi JIANG
1
;
Hong-chen LIU
;
Xia WU
;
Chun-zhen FENG
;
Ping CHANG
;
Xian-hua ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Anti-Bacterial Agents; blood; pharmacokinetics; Chromatography, High Pressure Liquid; Feasibility Studies; Female; Humans; Male; Ornidazole; analysis; blood; pharmacokinetics; Saliva; metabolism; Young Adult
- From: Journal of Southern Medical University 2010;30(9):2108-2110
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of ornidazole in the salivary and serum of healthy adults and explore the feasibility of monitoring serum drug concentration with salivary.
METHODSSix volunteers received a single dose of 0.6 g ornidazole via intravenous infusion. The concentrations of ornidazole in the saliva and serum were assayed by high-performance liquid chomatography, and the correlation of the drug concentrations in saliva to that in serum was analyzed.
RESULTSThe concentration of ornidazole in the saliva was strongly associated with that in the serum (r = 0.825-0.969), and the ratio of saliva-to-serum concentration (S/P) of ornidazole was 0.99 ± 0.13.
CONCLUSIONDetection of saliva ornidazole concentration is feasible for monitoring the therapeutic concentration of ornidazole.
