Effect of spray drying process on physical properties and dissolution of tanshinone.
- Author:
Yan-Rong JIANG
;
Zhen-Hai ZHANG
;
Dong-Mei DING
;
Hong-Mei YAN
;
E SUN
;
Xiao-Bin JIA
- Publication Type:Journal Article
- MeSH:
Chemistry, Pharmaceutical;
methods;
Diterpenes, Abietane;
chemistry;
Drugs, Chinese Herbal;
chemistry;
Particle Size;
Solubility
- From:
China Journal of Chinese Materia Medica
2014;39(5):817-820
- CountryChina
- Language:Chinese
-
Abstract:
In order to improve the dissolution in vitro of components by processing tanshinone with the pray drying method, the physical properties of tanshinone power was analyzed by BET, differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction, and its dissolution in vitro was also investigated. The results of characterization showed decreased power size and increased specific surface area of tanshinone powder, and its existence in an amorphous state. Within 4 h, the accumulated dissolutions of tanshinone I and tanshinone II(A) in components of tanshinone reached 78.3%, 81.9%, respectively. Therefore, the spray-drying method was conducive to enhance the dissolution of components of tanshinone.
