Study on self-microemulsifying membrane controlled-release drop pill of hawthorn leaves flavonoids.
- Author:
Jin-Xuan WANG
;
Hong-Zhang HUANG
;
Ning LI
;
Chong-Kai GAO
- Publication Type:Journal Article
- MeSH:
Animals;
Chemistry, Pharmaceutical;
Crataegus;
chemistry;
Delayed-Action Preparations;
chemistry;
pharmacokinetics;
Drugs, Chinese Herbal;
chemistry;
pharmacokinetics;
Flavonoids;
chemistry;
pharmacokinetics;
Male;
Plant Leaves;
chemistry;
Rats;
Rats, Sprague-Dawley
- From:
China Journal of Chinese Materia Medica
2014;39(5):821-827
- CountryChina
- Language:Chinese
-
Abstract:
To prepare the hawthorn leaves flavonoids self-microemulsifying membrane controlled-release coated drop pill, and to study its release rate in vitro and pharmacokinetics study in vivo. In order to improve the dissolution of hawthorn leaves flavonoids, self-microemulsifying technology was used to prepare the hawthorn leaves flavonoids self-microemulsion. Hawthorn leaves flavonoids self-microemulsifying drop pill was prepared with the PEG 6000. Studies were made on the in vitro release of flavonoids from hawthorn leaves self-micro-emulsifying membrane-moderated coated drop pills and the in vivo pharmacokinetic in rats. The prescription of flavonoids from hawthorn leaves self-micro-emulsifying drop pills was 0.25 g of flavonoids from hawthorn leaves, 0.25 g of iodophenyl maleimide, 0.375 g of polyethylene glycol 400, 0.375 g of cremophor RH 40 and 2 g of polyethylene glycol 6000. The optimized prescription was 4 g of ethyl cellulose 20, 0.64 g of polyethylene glycol 400, 1.8 g of diethyl phthalate, and the weight of coating materials increased by 3.5%. Flavonoids from hawthorn leaves self-micro-emulsifying membrane-moderated coated drop pills complied with the design of sustained-release in 12 h in terms of in vitro release and in vivo pharmacokinetic parameters in rats, and its bioavailability was 2.47 times of quick-release drop pills. Slightly soluble flavonoids from hawthorn leaves could be made into sustained-release preparations by the self-micro-emulsifying and coating technology.
