Advance in studies on neuroprotective mechanism of Uncariae Ramulus Cum Uncis.
- Author:
Fang-Fang WEI
;
Chang-Qing ZENG
;
Yu-Hong ZHAO
;
Lin LIU
- Publication Type:Journal Article
- MeSH:
Animals;
Calcium;
metabolism;
Drugs, Chinese Herbal;
pharmacology;
Free Radical Scavengers;
pharmacology;
Humans;
Inflammation Mediators;
metabolism;
Neuroprotective Agents;
pharmacology;
Neurotransmitter Agents;
metabolism;
Uncaria;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(14):2603-2607
- CountryChina
- Language:Chinese
-
Abstract:
The Uncariae Ramulus Cum Uncis is a commonly used traditional Chinese medicine. In recent years, many studies have revealed its prominent neuroprotection function. The active ingredients in Uncariae Ramulus Cum Uncis could protect the nervous system in a multi-path and multi-target manner. Uncariae Ramulus Cum Uncis shows the neuroprotective effect by resisting oxidation, scavenging free radicals, modulating neurotransmitters and their related receptors, regulating the inflammatory factors and their related pathways, attenuating neuron apoptosis, reducing intracellular Ca2+ overloads and mitigating neurodegeneration. In this paper, the authors summarized the advance in studies on neuroprotective mechanisms of Uncariae Ramulus Cum Uncis.
