A new flavonone from seeds of Alpinia katsumadai and its neuroprotective effect on PC12 cells.
- Author:
Ben-Ru XIN
;
Shou-Juan REN
;
Jie LI
- Publication Type:Journal Article
- MeSH:
Alpinia;
chemistry;
Animals;
Cell Death;
drug effects;
Cholestenones;
chemistry;
isolation & purification;
pharmacology;
Cinnamates;
chemistry;
isolation & purification;
pharmacology;
DNA Fragmentation;
drug effects;
Neuroprotective Agents;
chemistry;
isolation & purification;
pharmacology;
Oxidative Stress;
drug effects;
PC12 Cells;
Rats;
Reactive Oxygen Species;
metabolism;
Seeds;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(14):2674-2678
- CountryChina
- Language:English
-
Abstract:
A new flavonone, named as (2R, 3S)-pinobanksin-3-cinnamate(1), together with six known compounds, pinocem-brin (2), pinobanksin (3), 3-O-acetylpinobanksin (4), galangin (5), kumatakenin(6), and 3-methylkaempferol (7), were isolated from a 95% ethanol extract of seeds of Alpinia katsumadai through a combination of various chromatographic techniques, including silica gel and Sephadex LH-20. The structure of compound 1 was elucidated by spectroscopic data analysis. Compound 1 exhibits a potent neuroprotective effect against the corticosterone-damaged PC12 cells, which may be underlying the effect by scavenging intracellular ROS.
