Lignans isolated from stems of Sambucus williamsii and their proliferation effects on UMR106 cells.
- Author:
Meng-Meng XU
;
Ying-Hui DUAN
;
Hui-Hui XIAO
;
Yi DAI
;
Zhen-Zhong WANG
;
Man-Sau WONG
;
Xin-Sheng YAO
;
Wei XIAO
- Publication Type:Journal Article
- MeSH:
Cell Line;
Cell Proliferation;
drug effects;
Lignans;
isolation & purification;
pharmacology;
Osteoblasts;
cytology;
drug effects;
Plant Stems;
chemistry;
Sambucus;
chemistry
- From:
China Journal of Chinese Materia Medica
2014;39(14):2684-2688
- CountryChina
- Language:Chinese
-
Abstract:
The present study aims to investigate the lignan constituents from Sambucus williamsii and their proliferation effects on osteoblast-like UMR106 cells. Seven compounds were isolated and purified by macroporous resin D101, silica gel, Sephadex LH-20, Toyopearl HW-40, ODS column chromatographies and Preparative HPLC(C-18). Their structures were elucidated by spectroscopic methods as threo-guaiacylglycerol-beta-0-4'-conifery ether (1), lirioresinol A (2), 1-hydroxypinoresinol (3), 5-methoxybalanophonin (4), balanophonin (5), 5-methoxy-trans-dihydrodehydrodiconiferyl alcohol (6), and p-hydroxybenzaldehyde (7). Compounds 3-7 were obtained from this genus for the first time. The proliferation effects of all isolated compounds on osteoblast-like UMR106 cells were determined. Compounds 1-7 (1 x 10(-12)-1 x 10(-7) mol x L(-1)) increased UMR106 cell proliferation to some extent.
