Advance in studies on natural antidepressant drugs and cytochrome P450.
- Author:
Lu ZHANG
;
Fei-hu WANG
;
Sai-zhen CHEN
;
Jian-chun PAN
- Publication Type:Journal Article
- MeSH:
Animals;
Antidepressive Agents;
pharmacology;
Cytochrome P-450 Enzyme Inhibitors;
pharmacology;
Cytochrome P-450 Enzyme System;
metabolism;
Depression;
drug therapy;
enzymology;
Drugs, Chinese Herbal;
pharmacology;
Humans
- From:
China Journal of Chinese Materia Medica
2015;40(5):828-832
- CountryChina
- Language:Chinese
-
Abstract:
In the fast pace of modern life and under the heavy work pressure, the prevalence of depression has increased year by year. Meanwhile, the demands for antidepressant drugs have also grown, especially the high-efficiency and low-toxicity natural antidepressant drugs, mainly including polyphenols, flavonoids, organic acids, alkaloids and terpenoids. Cytochrome P450 (CYP450) is a type of enzymes involving oxidative metabolism of drugs in vivo, and can change the pharmacokinetics and efficacy of drugs. Therefore, it is of important significant to define the effect of natural antidepressant drugs on CYP450 in human bodies, in order to improve the rational clinical medication, avoid drug interactions and reduce adverse reactions.
