Research development of the chemical material basis of Alisma orientalis and its toxicity.
- Author:
Chun-fei WANG
;
Xu-dong CHENG
;
Jun-fei GU
;
Jia-rui YUAN
;
Bing-jie ZHAO
;
Li ZHANG
;
Juan CHEN
;
Liang FENG
;
Xiao-bin JIA
- Publication Type:Journal Article
- MeSH:
Alisma;
chemistry;
toxicity;
Animals;
Drugs, Chinese Herbal;
chemistry;
toxicity;
Humans;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2015;40(5):840-846
- CountryChina
- Language:Chinese
-
Abstract:
Alisma orientalis is a traditional herb medicine commonly used in clinical. With the increasing report of its toxicity in clinical, the renal toxicity of Alisma orientalis has got gradually attention. This paper systematically reviews the research on the chemical material basis of Alisma orientalis including its chemical composition and toxicity of ingredients; and also declares its toxic ingredients and targets according to Network toxicology. Based on the controversy on renal toxicity of Alisma orientalis, we analyzed the possible reasons that may be associated with renal toxicity. It might be associated with the differences of the material basis composition and regulatory toxicology network, differences in employed processing technology, the metabolic function leading to accumulation of compounds, dosage and duration of the experiment and compatibility. The review provides possible reference and ideas for the quality control and rational use of Alisma orientalis.
