Advance in studies on hepatoprotective effect of Salvia miltiorrhiza and its main components.
- Author:
Yuan YUAN
;
Qin WU
;
Jing-shan SHI
;
Xiu-ping CHEN
- Publication Type:Journal Article
- MeSH:
Animals;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Humans;
Liver;
drug effects;
Protective Agents;
chemistry;
pharmacology;
Salvia miltiorrhiza;
chemistry
- From:
China Journal of Chinese Materia Medica
2015;40(4):588-593
- CountryChina
- Language:Chinese
-
Abstract:
Dried roots and rhizomes of Salvia miltiorrhiza (Danshen) are among the most commonly used traditional Chinese medicines in clinic. The material basis for its efficacy mainly includes hydrophobic tanshinones and hydrophilic salvianolic acids. The traditional effects of Danshen are "removing stasis and relieving pain, activating blood to promote menstruation, clearing heart fire and tranquilization". According to modern pharmacological studies, Danshen and its main components have cardiovascular and cerebrovascular protective effect. Recent studies showed that Danshen and its main components also demonstrated protective effects on liver injury models induced by carbon tetrachloride, D-galactosamine, acetaminophen and alcohol. In this paper, the hepatoprotective effect and mechanism of Danshen were summarized and studied.
