A novel chromene with anti-tumor activities from fungus Phomopsis sp.
- Author:
Zhi-jun YANG
;
Yu YIN
;
Mei GE
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
chemistry;
pharmacology;
Ascomycota;
chemistry;
Benzopyrans;
chemistry;
pharmacology;
Cell Line, Tumor;
Fluorouracil;
chemistry;
pharmacology;
Humans;
Isocoumarins;
chemistry;
pharmacology;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2015;40(4):667-671
- CountryChina
- Language:Chinese
-
Abstract:
A new chromene (1) and six known compounds identified as 6-hydroxymellein (2), 6-hydroxy-5-methylmellein (3) nectriapyrone (4), chermesinone A(5), chermesinone B(6), and pomopxanthone A(7), were isolated in our investigation of the cytotoxic constituents from the fermented rice substrate of endophytic fungus Phomopsis sp. HCCB03519. The structures of these com pounds were elucidated through spectroscopic data analysis. All compounds exhibited inhibitory activities against cancer cell lines. Compound 7 showed stronger inhibition against cancer cells than the positive control 5-Fu.
