The changes of estrogen receptor (ER) and progesterone receptor (PR) mRNAs in endometrium with endometriosis.
- Author:
Hui ZHENG
1
;
Hong-yi LI
;
Zi-neng WANG
;
Zhi-quan BAI
;
Xiao-ye LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Endometriosis; metabolism; Endometrium; metabolism; Female; RNA, Messenger; genetics; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; genetics; metabolism; Receptors, Progesterone; genetics; metabolism
- From: Chinese Journal of Applied Physiology 2004;20(2):194-196
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the expression of ER and PR mRNAs in endometrium with endometriosis.
METHODSThe rat model of endometriosis was established, and the expression of ER, PR mRNAs in the endometrium was examined by reverse transcription-polymerase chain reaction (RT-PCR).
RESULTSThe expression of ER and PR mRNAs in ectopic endometrium was significantly lower than that in eutopic and normal endometrium (P < 0.01). But no difference was observed between eutopic and normal endometrium (P > 0.05). Ratio of ER/PR mRNA in ectopic endometrium was larger than that in eutopic and in normal endometrium (P < 0.01).
CONCLUSIONThe result illuminates that the increased ER plays a vital role in the onset of endometriosis.
