Effect of bombesin on IFN-induced fever and AVP content in brain of rats.
- Author:
Xiao-yang ZHOU
1
;
Shu-feng ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arginine Vasopressin; metabolism; Body Temperature Regulation; drug effects; Bombesin; pharmacology; Brain; drug effects; metabolism; Fever; chemically induced; physiopathology; Interferon-alpha; adverse effects; Male; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2004;20(3):300-303
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo determine whether bombesin prevents IFN-alpha-induced fever and it's possible mechanism.
METHODSEffects of BN on changes in body temperature and arginine vasopressin(AVP) content in the ventral septal area(VSA) and hypothalamus were measured in the rats following intracerebroventricular (ICV) injection of IFN-alpha.
RESULTS(1) IFN-alpha produced a dose-dependent rise in colonic temperature simultaneously with increase in AVP content in the VSA in the rats. (2) BN produced a dose-dependent hypothermia and significantly elevated AVP content in the VSA in rats. (3) BN injected intracerebroventricularly at 30 min after IFN-alpha prevented the increase in colonic temperature which recovered to the control level as well as AVP content in the VSA in rats at 150 min.
CONCLUSIONAVP in the VSA may play a role in IFN-alpha-induced fever. AVP in the VSA may play a partial role in the BN antipyretic action and hypothermic action.
