Heat injury induced apoptosis in rat striatum neurons.
- Author:
Wen-Hong FAN
1
;
Min LI
;
Lu-Ming WANG
;
Ming FAN
;
Cheng XING
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Corpus Striatum; cytology; Heat-Shock Response; Hot Temperature; adverse effects; Membrane Potential, Mitochondrial; Neurons; cytology; pathology; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2004;20(4):342-344
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effect of hyperthermia on apoptosis of cultivated striatum neurons in the rat.
METHODSAfter 30 min hyperthermia in 43 degrees, the Ca2+ concentration, the mitochondria membrane potential of the neuron were detected by Laser Scanning Confocal Microscopy (LSCM). The apoptosis of striatum neurons was detected by TUNEL staining.
RESULTSHeat stress at 43 degrees C for 40 min caused an increase in the Ca2+ concentration of striatum neurons and a decrease in the mitochondria membrane potential of the striatum neurons.
CONCLUSIONThe striatum shows more apoptosis neurons after heat stress.
